CATH Domain 4wv5A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.34	Substrate Binding Domain Of DNAk; Chain A, domain 1
	2.60.34.10	Substrate Binding Domain Of DNAk; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily	Substrate Binding Domain Of DNAk; Chain A, domain 1
Functional Family	Heat shock 70 kDa

Enzyme Information

UniProtKB Entries (1)

HS71B_HUMAN

Homo sapiens

Heat shock 70 kDa protein 1B

PDB Structure

PDB	4WV5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The novolactone natural product disrupts the allosteric regulation of hsp70. Hassan, A.Q., Kirby, C.A., Zhou, W., Schuhmann, T., Kityk, R., Kipp, D.R., Baird, J., Chen, J., Chen, Y., Chung, F., Hoepfner, D., Movva, N.R., Pagliarini, R., Petersen, F., Quinn, C., Quinn, D., Riedl, R., Schmitt, E.K., Schitter, A., Stams, T., Studer, C., Fortin, P.D., Mayer, M.P., Sadlish, H. Chem.Biol.