CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family |
Enzyme Information
| 4.1.2.51 |
2-dehydro-3-deoxy-D-gluconate aldolase.
based on mapping to UniProt Q6KZI8
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde.
-!- The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. -!- In the direction of aldol synthesis the enzyme catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D- galactonate at a similar ratio. -!- It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. -!- Cf. EC 4.1.2.14.
|
| 4.1.2.14 |
2-dehydro-3-deoxy-phosphogluconate aldolase.
based on mapping to UniProt Q6KZI8
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
-!- The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55). -!- Also acts on 2-oxobutanoate.
|
| 4.1.2.21 |
2-dehydro-3-deoxy-6-phosphogalactonate aldolase.
based on mapping to UniProt Q6KZI8
2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate.
-!- The enzyme catalyzes the last reaction in a D-galactose degradation pathway. -!- Cf. EC 4.1.2.55.
|
| 4.1.2.- |
Aldehyde-lyases.
based on mapping to UniProt Q6KZI8
|
UniProtKB Entries (1)
| Q6KZI8 |
KDGA_PICTO
Picrophilus torridus DSM 9790
2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase
|
PDB Structure
| PDB | 4UXD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases: The Structures of Picrophilus torridus 2-Keto-3-deoxygluconate Aldolase and Sulfolobus solfataricus 2-Keto-3-deoxy-6-phosphogluconate Aldolase in Complex with 2-Keto-3-deoxy-6-phosphogluconate.
Biochemistry
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