CATH Domain 4tsxA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family	POL polyprotein

Enzyme Information

UniProtKB Entries (1)

F2WR39_9HIV1

Human immunodeficiency virus 1

Integrase

PDB Structure

PDB	4TSX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The mechanism of H171T resistance reveals the importance of N -protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Slaughter, A., Jurado, K.A., Deng, N., Feng, L., Kessl, J.J., Shkriabai, N., Larue, R.C., Fadel, H.J., Patel, P.A., Jena, N., Fuchs, J.R., Poeschla, E., Levy, R.M., Engelman, A., Kvaratskhelia, M. Retrovirology