CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase M1, alanyl aminopeptidase, C-terminal domain
Functional Family Aminopeptidase N

Enzyme Information

3.4.11.2
Membrane alanyl aminopeptidase.
based on mapping to UniProt P04825
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
-!- Is not activated by heavy metal ions. -!- Belongs to peptidase family M1. -!- Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.

UniProtKB Entries (1)

P04825
AMPN_ECOLI
Escherichia coli K-12
Aminopeptidase N

PDB Structure

PDB 4Q4I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli Aminopeptidase N
Ganji, R.J., Reddi, R., Gumpena, R., Marapaka, A.K., Arya, T., Sankoju, P., Bhukya, S., Addlagatta, A.
Protein Sci.
CATH-Gene3D is a Global Biodata Core Resource Learn more...