CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family

Enzyme Information

3.1.1.84
Cocaine esterase.
based on mapping to UniProt Q9L9D7
Cocaine + H(2)O = ecgonine methyl ester + benzoate.
-!- Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy.

UniProtKB Entries (1)

Q9L9D7
COCE_RHOSM
Rhodococcus sp. MB1 'Bresler 1999'
Cocaine esterase

PDB Structure

PDB 4P08
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification.
Fang, L., Chow, K.M., Hou, S., Xue, L., Chen, X., Rodgers, D.W., Zheng, F., Zhan, C.G.
Acs Chem.Biol.
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