CATH Domain 4o7uA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Thymidylate synthase

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt Q834R3

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_ENTFA

Enterococcus faecalis V583

Thymidylate synthase

PDB Structure

PDB	4O7U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors. Catalano, A., Luciani, R., Carocci, A., Cortesi, D., Pozzi, C., Borsari, C., Ferrari, S., Mangani, S. Eur.J.Med.Chem.