CATH Domain 4n4oE02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.850	Hydroxylamine Oxidoreductase; Chain A, domain 2
	1.20.850.10	Hydroxylamine Oxidoreductase; Chain A, domain 2

Domain Context

CATH Clusters

Superfamily	Hydroxylamine Oxidoreductase; Chain A, domain 2
Functional Family	Hydroxylamine oxidoreductase

Enzyme Information

1.7.2.6

Hydroxylamine dehydrogenase.

based on mapping to UniProt Q50925

(1) Hydroxylamine + H(2)O + 4 ferricytochrome c = nitrite + 4 ferrocytochrome c + 5 H(+). (2) Hydroxylamine + 3 ferricytochrome c = nitric oxide + 3 ferrocytochrome c + 3 H(+).

-!- The enzymes from the nitrifying bacterium Nitrosomonas europaea and the methylotrophic bacterium Methylococcus capsulatus are hemoproteins with seven c-type hemes and one specialized P460-type heme per subunit. -!- The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate. -!- While nitrite is the main product, the enzyme from Nitrosomonas europaea can produce nitric oxide as well. -!- Formerly EC 1.7.3.4.

UniProtKB Entries (1)

Q82V11

Q82V11_NITEU

Nitrosomonas europaea ATCC 19718

Uncharacterized protein

PDB Structure

PDB	4N4O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis of Biological NO Generation by Octaheme Oxidoreductases. Maalcke, W.J., Dietl, A., Marritt, S.J., Butt, J.N., Jetten, M.S., Keltjens, J.T., Barends, T.R., Kartal, B. J.Biol.Chem.