CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family |
Enzyme Information
| 1.1.99.38 |
2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent).
based on mapping to UniProt Q8G907
2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy- scyllo-inosose + 5'-deoxyadenosine + L-methionine.
-!- Involved in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family. -!- The enzyme from Bacillus circulans was shown to be a radical S-adenosyl-L-methionine (SAM) enzyme. -!- Cf. EC 1.1.1.329.
|
UniProtKB Entries (1)
| Q8G907 |
BTRN_BACCI
Bacillus circulans
S-adenosyl-L-methionine-dependent 2-deoxy-scyllo-inosamine dehydrogenase
|
PDB Structure
| PDB | 4M7T |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry.
Proc.Natl.Acad.Sci.USA
|
