CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1000 | HAD superfamily/HAD-like |
Domain Context
CATH Clusters
| Superfamily | HAD superfamily/HAD-like |
| Functional Family | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC |
Enzyme Information
| 3.1.3.103 |
3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase.
based on mapping to UniProt Q8A712
3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H(2)O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate.
-!- The enzyme, characterized from the bacterium Bacteroides thetaiotaomicron, is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate (Kdn). -!- Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
|
UniProtKB Entries (1)
| Q8A712 |
KDGGP_BACTN
Bacteroides thetaiotaomicron VPI-5482
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid phosphatase
|
PDB Structure
| PDB | 4HGR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis.
Biochemistry
|
