CATH Domain 4gnkE00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1230	Phospholipase C Beta; Chain: A
	1.20.1230.10	Phospholipase C beta, distal C-terminal domain

Domain Context

CATH Clusters

Superfamily	Phospholipase C beta, distal C-terminal domain
Functional Family	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Enzyme Information

3.1.4.11

Phosphoinositide phospholipase C.

based on mapping to UniProt Q01970

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (2)

P21279	GNAQ_MOUSE Mus musculus Guanine nucleotide-binding protein G(q) subunit alpha
Q01970	PLCB3_HUMAN Homo sapiens 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

PDB Structure

PDB	4GNK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Full-length G alpha (q)-phospholipase C-beta 3 structure reveals interfaces of the C-terminal coiled-coil domain. Lyon, A.M., Dutta, S., Boguth, C.A., Skiniotis, G., Tesmer, J.J. Nat.Struct.Mol.Biol.