CATH Classification

Domain Context

CATH Clusters

Superfamily Indigoidine synthase domain
Functional Family Indigoidine synthase A family protein

Enzyme Information

4.2.1.70
Pseudouridylate synthase.
based on mapping to UniProt P33025
Uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O.
-!- The reaction it readily reversible. -!- While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo.

UniProtKB Entries (1)

P33025
PSUG_ECOLI
Escherichia coli K-12
Pseudouridine-5'-phosphate glycosidase

PDB Structure

PDB 4GIM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Pseudouridine monophosphate glycosidase: a new glycosidase mechanism.
Huang, S., Mahanta, N., Begley, T.P., Ealick, S.E.
Biochemistry
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