CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
| Superfamily | NADP-dependent oxidoreductase domain |
| Functional Family | Aldo-keto reductase family 1 member C3 |
Enzyme Information
| 1.1.1.188 |
Prostaglandin-F synthase.
based on mapping to UniProt P42330
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.
-!- Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2). -!- Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
|
| 1.1.1.112 |
Indanol dehydrogenase.
based on mapping to UniProt P42330
Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.
-!- 3(20)-alpha-hydroxysteroids are also oxidized, more slowly.
|
| 1.3.1.20 |
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
based on mapping to UniProt P42330
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
|
| 1.1.1.239 |
3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)).
based on mapping to UniProt P42330
Testosterone + NAD(+) = androstenedione + NADH.
-!- Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids. -!- Different from EC 1.1.1.50 or EC 1.1.1.213. -!- Formerly EC 1.1.1.63.
|
| 1.1.1.357 |
3-alpha-hydroxysteroid 3-dehydrogenase.
based on mapping to UniProt P42330
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
-!- The enzyme acts on multiple 3-alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. -!- The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. -!- This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).
|
| 1.-.-.- |
Oxidoreductases.
based on mapping to UniProt P42330
|
| 1.1.1.64 |
Testosterone 17-beta-dehydrogenase (NADP(+)).
based on mapping to UniProt P42330
Testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH.
-!- Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
|
UniProtKB Entries (1)
| P42330 |
AK1C3_HUMAN
Homo sapiens
Aldo-keto reductase family 1 member C3
|
PDB Structure
| PDB | 4DBS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.
Bioorg.Med.Chem.Lett.
|
