CATH Domain 4d9rA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.46

Complement factor D.

based on mapping to UniProt P00746

Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.

-!- A component of the alternative pathway of complement activation. -!- This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00746

CFAD_HUMAN

Homo sapiens

Complement factor D

PDB Structure

PDB	4D9R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibiting alternative pathway complement activation by targeting the factor d exosite. Katschke, K.J., Wu, P., Ganesan, R., Kelley, R.F., Mathieu, M.A., Hass, P.E., Murray, J., Kirchhofer, D., Wiesmann, C., van Lookeren Campagne, M. J.Biol.Chem.