CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family |
Enzyme Information
| 1.3.5.2 |
Dihydroorotate dehydrogenase (quinone).
based on mapping to UniProt Q08210
(S)-dihydroorotate + a quinone = orotate + a quinol.
-!- This Class 2 dihydroorotate dehydrogenase enzyme contains FMN. -!- The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane. -!- The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. -!- The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates. -!- Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not. -!- Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- Formerly EC 1.3.99.11.
|
UniProtKB Entries (1)
| Q08210 |
PYRD_PLAF7
Plasmodium falciparum 3D7
Dihydroorotate dehydrogenase (quinone), mitochondrial
|
PDB Structure
| PDB | 4CQ8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth.
J.Biol.Chem.
|
