CATH Domain 4chtA03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.20	Topoisomerase I; domain 3
	2.70.20.10	Topoisomerase I, domain 3

Domain Context

CATH Clusters

Superfamily	Topoisomerase I, domain 3
Functional Family	DNA topoisomerase

Enzyme Information

5.6.2.2

DNA topoisomerase.

based on mapping to UniProt Q13472

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.

-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.

UniProtKB Entries (1)

Q13472

TOP3A_HUMAN

Homo sapiens

DNA topoisomerase 3-alpha

PDB Structure

PDB	4CHT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and Mechanistic Insight Into Holliday-Junction Dissolution by Topoisomerase Iiialpha and Rmi1 Bocquet, N., Bizard, A.H., Abdulrahman, W., Larsen, N.B., Faty, M., Cavadini, S., Bunker, R.D., Kowalczykowski, S.C., Cejka, P., Hickson, I.D., Thoma, N.H. Nat.Struct.Mol.Biol.