CATH Domain 4c27B00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.630	Cytochrome p450
	1.10.630.10	Cytochrome P450

Domain Context

CATH Clusters

Superfamily	Cytochrome P450
Functional Family

Enzyme Information

1.14.14.154

Sterol 14-alpha-demethylase.

based on mapping to UniProt Q7Z1V1

A 14-alpha-methylsteroid + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = a Delta(14)-steroid + formate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O.

-!- This cytochrome P450 (heme-thiolate) enzyme acts on a range of steroids with a 14-alpha-methyl group, such as obtusifoliol and lanosterol. -!- The enzyme catalyzes a hydroxylation and a reduction of the 14-alpha- methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond. -!- Formerly EC 1.14.13.70.

UniProtKB Entries (1)

Q7Z1V1

CP51_TRYCC

Trypanosoma cruzi strain CL Brener

Sterol 14-alpha demethylase

PDB Structure

PDB	4C27
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Binding Mode and Potency of N-Indolyl-Oxopyridinyl-4-Amino-Propanyl-Based Inhibitors Targeting Trypanosoma Cruzi Cyp51 Vieira, D.F., Choi, J.Y., Calvet, C.M., Siqueira-Neto, J.L., Johnston, J.B., Kellar, D., Gut, J., Cameron, M.D., Mckerrow, J.H., Roush, W.R., Podust, L.M. J.Med.Chem.