CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1190 | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase |
|
3.40.1190.10 | Mur-like, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Mur-like, catalytic domain |
| Functional Family |
Enzyme Information
| 6.3.2.37 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase.
based on mapping to UniProt Q9WY79
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + D-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D- glutamyl-N(epsilon)-D-lysine.
-!- Involved in the synthesis of cell-wall peptidoglycan. -!- The D-lysine is attached to the peptide chain at the N(6) position. -!- The enzyme from Thermotoga maritima also performs the reaction of EC 6.3.2.7. -!- Formerly EC 6.3.2.n1.
|
| 6.3.2.7 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase.
based on mapping to UniProt Q9WY79
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D- glutamyl-L-lysine.
-!- Involved in the synthesis of a cell-wall peptide. -!- This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 adds 2,6-diaminopimelate instead.
|
UniProtKB Entries (1)
| Q9WY79 |
MURE_THEMA
Thermotoga maritima MSB8
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase
|
PDB Structure
| PDB | 4BUB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mreb and Murg as Scaffolds for the Cytoplasmic Steps of Peptidoglycan Biosynthesis
Environ.Microbiol.
|
