CATH Domain 4bccA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Prolyl endopeptidase

Enzyme Information

3.4.21.26

Prolyl oligopeptidase.

based on mapping to UniProt P23687

Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.

-!- Found in vertebrates, plants and Flavobacterium. -!- Generally cytosolic, commonly activated by thiol compounds. -!- Belongs to peptidase family S9A. -!- Formerly EC 3.4.22.18.

UniProtKB Entries (1)

P23687

PPCE_PIG

Sus scrofa

Prolyl endopeptidase

PDB Structure

PDB	4BCC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy. Van Der Veken, P., Fulop, V., Rea, D., Gerard, M., Van Elzen, R., Joossens, J., Cheng, J.D., Baekelandt, V., De Meester, I., Lambeir, A.M., Augustyns, K. J.Med.Chem.