CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.170 | Putative methyltransferase TM0872, insert domain |
Domain Context
CATH Clusters
| Superfamily | Putative methyltransferase TM0872, insert domain |
| Functional Family | Ribosomal RNA small subunit methyltransferase H |
Enzyme Information
| 2.1.1.199 |
16S rRNA (cytosine(1402)-N(4))-methyltransferase.
based on mapping to UniProt P60390
S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L- homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.
-!- RsmH catalyzes the N(4)-methylation of cytosine(1402) and RsmI (EC 2.1.1.198) catalyzes the 2'-O-methylation of cytosine(1402) in 16S rRNA. -!- Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.
|
UniProtKB Entries (1)
| P60390 |
RSMH_ECOLI
Escherichia coli K-12
Ribosomal RNA small subunit methyltransferase H
|
PDB Structure
| PDB | 3TKA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA.
J.Struct.Biol.
|
