CATH Domain 3tftA02

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

2.6.1.62

Adenosylmethionine--8-amino-7-oxononanoate transaminase.

based on mapping to UniProt P9WQ81

S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4- methylthio-2-oxobutanoate + 7,8-diaminononanoate.

-!- S-adenosylhomocysteine can also act as donor.

BIOA_MYCTU

Mycobacterium tuberculosis H37Rv

Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

PDB	3TFT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis. Shi, C., Geders, T.W., Park, S.W., Wilson, D.J., Boshoff, H.I., Abayomi, O., Barry, C.E., Schnappinger, D., Finzel, B.C., Aldrich, C.C. J.Am.Chem.Soc.