CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit alpha

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P05132
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P61014
PPLA_MOUSE
Mus musculus
Cardiac phospholamban

PDB Structure

PDB 3O7L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dynamics connect substrate recognition to catalysis in protein kinase A.
Masterson, L.R., Cheng, C., Yu, T., Tonelli, M., Kornev, A., Taylor, S.S., Veglia, G.
Nat.Chem.Biol.
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