CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.20 | Dihydropteroate synthase-like |
Domain Context
CATH Clusters
| Superfamily | Dihydropteroate synthase-like |
| Functional Family | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) |
Enzyme Information
| 1.17.7.3 |
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin).
based on mapping to UniProt O67496
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + oxidized flavodoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin.
-!- Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria. -!- Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1).
|
UniProtKB Entries (1)
| O67496 |
ISPG_AQUAE
Aquifex aeolicus VF5
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
|
PDB Structure
| PDB | 3NOY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG.
J.Mol.Biol.
|
