CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.10 | Alanine racemase |
Domain Context
CATH Clusters
| Superfamily | Alanine racemase |
| Functional Family | Carboxynorspermidine/carboxyspermidine decarboxylase |
Enzyme Information
| 4.1.1.96 |
Carboxynorspermidine decarboxylase.
based on mapping to UniProt A8FNH9
(1) Carboxynorspermidine = bis(3-aminopropyl)amine + CO(2). (2) Carboxyspermidine = spermidine + CO(2).
-!- Part of a bacterial polyamine biosynthesis pathway. -!- The enzyme is essential for biofilm formation in the bacterium Vibrio cholerae. -!- The enzyme from Campylobacter jejuni only produces spermidine in vivo even though it shows activity with carboxynorspermidine in vitro.
|
UniProtKB Entries (1)
| A8FNH9 |
NSPC_CAMJ8
Campylobacter jejuni subsp. jejuni 81116
Carboxynorspermidine/carboxyspermidine decarboxylase
|
PDB Structure
| PDB | 3N29 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
J.Biol.Chem.
|
