CATH Domain 3lpyA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.330	RRM (RNA recognition motif) domain

Domain Context

CATH Clusters

Superfamily	3.30.70.330
Functional Family

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q9UNP9

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q9UNP9

PPIE_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase E

PDB Structure

PDB	3LPY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Wang, Z., Song, J., Milne, T.A., Wang, G.G., Li, H., Allis, C.D., Patel, D.J. Cell(Cambridge,Mass.)