CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family Peptidylprolyl isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q62446
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q62446
FKBP3_MOUSE
Mus musculus
Peptidyl-prolyl cis-trans isomerase FKBP3

PDB Structure

PDB 3KZ7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Diversified targets of FKBP25 and its complex with rapamycin.
Galat, A., Thai, R., Stura, E.A.
Int.J.Biol.Macromol.
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