CATH Domain 3iw4A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Protein kinase C

Enzyme Information

2.7.11.13

Protein kinase C.

based on mapping to UniProt P17252

ATP + a protein = ADP + a phosphoprotein.

-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P17252

KPCA_HUMAN

Homo sapiens

Protein kinase C alpha type

PDB Structure

PDB	3IW4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes Wagner, J., von Matt, P., Sedrani, R., Albert, R., Cooke, N., Ehrhardt, C., Geiser, M., Rummel, G., Stark, W., Strauss, A., Cowan-Jacob, S.W., Beerli, C., Weckbecker, G., Evenou, J.P., Zenke, G., Cottens, S. J.Med.Chem.