CATH Domain 3hy8A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.110	Pnp Oxidase; Chain A
	2.30.110.10	Electron Transport, Fmn-binding Protein; Chain A

Domain Context

CATH Clusters

Superfamily	Electron Transport, Fmn-binding Protein; Chain A
Functional Family	PNPO isoform 11

Enzyme Information

1.4.3.5

Pyridoxal 5'-phosphate synthase.

based on mapping to UniProt Q9NVS9

(1) Pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'-phosphate + NH(3) + H(2)O(2). (2) Pyridoxine 5'-phosphate + O(2) = pyridoxal 5'-phosphate + H(2)O(2).

-!- In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5.

UniProtKB Entries (1)

Q9NVS9

PNPO_HUMAN

Homo sapiens

Pyridoxine-5'-phosphate oxidase

PDB Structure

PDB	3HY8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molecular basis of reduced pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder Musayev, F.N., Di Salvo, M.L., Saavedra, M.A., Contestabile, R., Ghatge, M.S., Haynes, A., Schirch, V., Safo, M.K. J.Biol.Chem.