CATH Domain 3hw4A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.91	Restriction Endonuclease
	3.40.91.90	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain

Domain Context

CATH Clusters

Superfamily	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
Functional Family	Polymerase acidic protein

Enzyme Information

3.1.-.-

Acting on ester bonds.

based on mapping to UniProt Q9Q0U9

UniProtKB Entries (1)

PA_I96A0

Influenza A virus (A/goose/Guangdong/1/1996(H5N1))

Polymerase acidic protein

PDB Structure

PDB	3HW4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Liang, S., Zhang, L., Chen, S., Li, X., Liu, Y., Bartlam, M., Rao, Z. J.Virol.