CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.3120 | Trigger factor, domain 2 |
|
1.10.3120.10 | Trigger factor, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Trigger factor, C-terminal domain |
| Functional Family |
Enzyme Information
| 5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt Q9WZF8
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
|
UniProtKB Entries (1)
| Q9WZF8 |
TIG_THEMA
Thermotoga maritima MSB8
Trigger factor
|
PDB Structure
| PDB | 3GU0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Promiscuous substrate recognition in folding and assembly activities of the trigger factor chaperone
Cell(Cambridge,Mass.)
|
