CATH Domain 3e3hA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.140	Metal-dependent hydrolases

Domain Context

CATH Clusters

Superfamily	Metal-dependent hydrolases
Functional Family	Parathion hydrolase

Enzyme Information

3.1.8.1

Aryldialkylphosphatase.

based on mapping to UniProt P0A434

An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.

-!- Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. -!- Inhibited by chelating agents. -!- Previously regarded as identical with EC 3.1.1.2.

UniProtKB Entries (1)

P0A434

OPD_BREDI

Brevundimonas diminuta

Parathion hydrolase

PDB Structure

PDB	3E3H
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities. Reeves, T.E., Wales, M.E., Grimsley, J.K., Li, P., Cerasoli, D.M., Wild, J.R. Protein Eng.Des.Sel.