CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.640 | Aspartate Aminotransferase; domain 2 |
|
3.40.640.10 | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
Domain Context
CATH Clusters
| Superfamily | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
| Functional Family | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase |
Enzyme Information
| 2.6.1.105 |
Lysine--8-amino-7-oxononanoate transaminase.
based on mapping to UniProt P53555
L-lysine + 8-amino-7-oxononanoate = (S)-2-amino-6-oxohexanoate + 7,8- diaminononanoate.
-!- Participates in the pathway for biotin biosynthesis. -!- The enzyme from the bacterium Bacillus subtilis cannot use S-adenosyl-L-methionine as amino donor and catalyzes an alternative reaction for the conversion of 8-amino-7-oxononanoate to 7,8- diaminononanoate (cf. EC 2.6.1.62). -!- Formerly EC 2.6.1.n2.
|
UniProtKB Entries (1)
| P53555 |
BIOK_BACSU
Bacillus subtilis subsp. subtilis str. 168
L-Lysine--8-amino-7-oxononanoate transaminase
|
PDB Structure
| PDB | 3DU4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Biochemistry
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