CATH Domain 3d4lA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Dipeptidyl peptidase 4

Enzyme Information

3.4.14.5

Dipeptidyl-peptidase IV.

based on mapping to UniProt P27487

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P27487

DPP4_HUMAN

Homo sapiens

Dipeptidyl peptidase 4

PDB Structure

PDB	3D4L
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design. Liang, G.B., Qian, X., Biftu, T., Singh, S., Gao, Y.D., Scapin, G., Patel, S., Leiting, B., Patel, R., Wu, J., Zhang, X., Thornberry, N.A., Weber, A.E. Bioorg.Med.Chem.Lett.