CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Elongation factor 4 |
Enzyme Information
| 3.6.5.n1 |
Elongation factor 4.
based on mapping to UniProt P60785
GTP + H(2)O = GDP + phosphate.
-!- The enzyme is required for accurate and efficient protein synthesis under certain stress conditions. -!- May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. -!- Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. -!- Binds to ribosomes in a GTP-dependent manner.
|
UniProtKB Entries (1)
| P60785 |
LEPA_ECOLI
Escherichia coli K-12
Elongation factor 4
|
PDB Structure
| PDB | 3CB4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The structure of LepA, the ribosomal back translocase.
Proc.Natl.Acad.Sci.Usa
|
