CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
| Superfamily | NADP-dependent oxidoreductase domain |
| Functional Family | Aldo-keto reductase family 1 member C3 |
Enzyme Information
| 1.3.1.20 |
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
based on mapping to UniProt Q04828
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
|
| 1.1.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt Q04828
|
| 1.1.1.149 |
20-alpha-hydroxysteroid dehydrogenase.
based on mapping to UniProt Q04828
17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha- hydroxyprogesterone + NAD(P)H.
-!- Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62).
|
| 1.1.1.112 |
Indanol dehydrogenase.
based on mapping to UniProt Q04828
Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.
-!- 3(20)-alpha-hydroxysteroids are also oxidized, more slowly.
|
UniProtKB Entries (1)
| Q04828 |
AK1C1_HUMAN
Homo sapiens
Aldo-keto reductase family 1 member C1
|
PDB Structure
| PDB | 3C3U |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid
J.Med.Chem.
|
