CATH Domain 3a6sA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.79	Nucleoside Triphosphate Pyrophosphohydrolase
	3.90.79.10	Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily	Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family	8-oxo-dGTP diphosphatase MutT

Enzyme Information

3.6.1.55

8-oxo-dGTP diphosphatase.

based on mapping to UniProt P08337

8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.

-!- This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. -!- It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).

UniProtKB Entries (1)

P08337

MUTT_ECOLI

Escherichia coli K-12

8-oxo-dGTP diphosphatase

PDB Structure

PDB	3A6S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base Nakamura, T., Meshitsuka, S., Kitagawa, S., Abe, N., Yamada, J., Ishino, T., Nakano, H., Tsuzuki, T., Doi, T., Kobayashi, Y., Fujii, S., Sekiguchi, M., Yamagata, Y. J.Biol.Chem.