CATH Domain 2zyzD01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1170	MutS, DNA mismatch repair protein, domain I
	3.40.1170.20	tRNA intron endonuclease, N-terminal domain

Domain Context

CATH Clusters

Superfamily	tRNA intron endonuclease, N-terminal domain
Functional Family	tRNA-splicing endonuclease

Enzyme Information

4.6.1.16

tRNA-intron lyase.

based on mapping to UniProt Q8ZVI1

PretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.

-!- The enzyme catalyzes the final stage in the maturation of tRNA molecules. -!- Formerly EC 3.1.27.9.

UniProtKB Entries (1)

Q8ZVI1

ENDA_PYRAE

Pyrobaculum aerophilum str. IM2

TRNA-splicing endonuclease

PDB Structure

PDB	2ZYZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Functional importance of crenarchaea-specific extra-loop revealed by an X-ray structure of a heterotetrameric crenarchaeal splicing endonuclease Yoshinari, S., Shiba, T., Inaoka, D.K., Itoh, T., Kurisu, G., Harada, S., Kita, K., Watanabe, Y. Nucleic Acids Res.