CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.150 | C2 domain |
Domain Context
CATH Clusters
| Superfamily | C2 domain |
| Functional Family | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase |
Enzyme Information
| 3.1.4.11 |
Phosphoinositide phospholipase C.
based on mapping to UniProt Q00722
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.
|
UniProtKB Entries (1)
| Q00722 |
PLCB2_HUMAN
Homo sapiens
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
|
PDB Structure
| PDB | 2ZKM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
General and versatile autoinhibition of PLC isozymes
Mol.Cell
|
