CATH Domain 2p3xA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1280	di-copper center containing domain from catechol oxidase
	1.10.1280.10	Di-copper center containing domain from catechol oxidase

Domain Context

CATH Clusters

Superfamily	Di-copper center containing domain from catechol oxidase
Functional Family	Polyphenol oxidase, chloroplastic

Enzyme Information

1.10.3.1

Catechol oxidase.

based on mapping to UniProt P43311

2 catechol + O(2) = 2 1,2-benzoquinone + 2 H(2)O.

-!- A type 3 copper protein that catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. -!- The enzyme also acts on a variety of substituted catechols. -!- It is different from tyrosinase, EC 1.14.18.1, which can catalyze both the monooxygenation of monophenols and the oxidation of catechols.

UniProtKB Entries (1)

P43311

PPO_VITVI

Vitis vinifera

Polyphenol oxidase, chloroplastic

PDB Structure

PDB	2P3X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cloning, sequencing, purification, and crystal structure of Grenache (Vitis vinifera) polyphenol oxidase. Virador, V.M., Reyes Grajeda, J.P., Blanco-Labra, A., Mendiola-Olaya, E., Smith, G.M., Moreno, A., Whitaker, J.R. J.Agric.Food Chem.