CATH Domain 2j9pA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.4.16.4

Serine-type D-Ala-D-Ala carboxypeptidase.

based on mapping to UniProt P39844

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

P39844

DACC_BACSU

Bacillus subtilis subsp. subtilis str. 168

D-alanyl-D-alanine carboxypeptidase DacC

PDB Structure

PDB	2J9P
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide. Sauvage, E., Duez, C., Herman, R., Kerff, F., Petrella, S., Anderson, J.W., Adediran, S.A., Pratt, R.F., Frere, J.M., Charlier, P. J. Mol. Biol.