CATH Domain 2gv9A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P04292 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.26.4	Ribonuclease H. based on mapping to UniProt P04292 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.

UniProtKB Entries (1)

DPOL_HHV1K

Human alphaherpesvirus 1 strain KOS

DNA polymerase catalytic subunit

PDB Structure

PDB	2GV9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Crystal structure of the herpes simplex virus 1 DNA polymerase. Liu, S., Knafels, J.D., Chang, J.S., Waszak, G.A., Baldwin, E.T., Deibel, M.R., Thomsen, D.R., Homa, F.L., Wells, P.A., Tory, M.C., Poorman, R.A., Gao, H., Qiu, X., Seddon, A.P. J.Biol.Chem.