CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
6 | Special |
|
6.10 | Helix non-globular |
|
6.10.250 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
6.10.250.3270 |
Domain Context
CATH Clusters
| Superfamily | 6.10.250.3270 |
| Functional Family |
Enzyme Information
| 1.5.5.2 |
Proline dehydrogenase.
based on mapping to UniProt Q72IB8
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.
-!- The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor. -!- In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88. -!- Both activities are carried out by the same enzyme in enterobacteria. -!- Formerly EC 1.5.99.8.
|
UniProtKB Entries (1)
| Q72IB8 |
PRODH_THET2
Thermus thermophilus HB27
Proline dehydrogenase
|
PDB Structure
| PDB | 2G37 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure and Kinetics of Monofunctional Proline Dehydrogenase from Thermus thermophilus.
J.Biol.Chem.
|
