CATH Domain 2ftpA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Hydroxymethylglutaryl-CoA lyase

Enzyme Information

4.1.3.26	3-hydroxy-3-isohexenylglutaryl-CoA lyase. based on mapping to UniProt Q9I2A0 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6- enoyl-CoA + acetate. -!- Also acts on the hydroxy derivative of farnesoyl-CoA.
4.1.3.4	Hydroxymethylglutaryl-CoA lyase. based on mapping to UniProt Q9I2A0 (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.

UniProtKB Entries (1)

LIUE_PSEAE

Pseudomonas aeruginosa PAO1

3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase

PDB Structure

PDB	2FTP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa Xiao, T., Evdokimova, E., Liu, Y., Kudritska, M., Savchenko, A., Pai, E.F., Edwards, A. To be Published