CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.3160
Functional Family Probable tRNA pseudouridine synthase D

Enzyme Information

5.4.99.27
tRNA pseudouridine(13) synthase.
based on mapping to UniProt Q8Q0M2
tRNA uridine(13) = tRNA pseudouridine(13).
-!- Pseudouridine synthase PusS from Escherichia coli specifically acts on uridine(13) in tRNA. -!- The Pus7 protein from Saccharomyces cerevisiae is a multisite- multisubstrate pseudouridine synthase that is able to modify uridine(13) in several yeast tRNAs, uridine(35) in the pre-tRNA(Tyr), uridine(35) in U2 small nuclear RNA, and uridine(50) in 5S rRNA.

UniProtKB Entries (1)

Q8Q0M2
TRUD_METMA
Methanosarcina mazei Go1
Probable tRNA pseudouridine synthase D

PDB Structure

PDB 1Z2Z
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of the Putative tRNA pseudouridine synthase D (TruD) from Methanosarcina mazei, Northeast Structural Genomics Target MaR1
Forouhar, F., Yong, W., Ciano, M., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L.
To be Published
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