CATH Domain 1y8xB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.290	Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A
	3.10.290.20	Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3

Domain Context

CATH Clusters

Superfamily	Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3
Functional Family	NEDD8-activating enzyme E1 catalytic subunit, variant

Enzyme Information

6.2.1.-

Acid--thiol ligases.

based on mapping to UniProt Q8TBC4

UniProtKB Entries (1)

UBA3_HUMAN

Homo sapiens

NEDD8-activating enzyme E1 catalytic subunit

PDB Structure

PDB	1Y8X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. Huang, D.T., Paydar, A., Zhuang, M., Waddell, M.B., Holton, J.M., Schulman, B.A. Mol.Cell