CATH Domain 1w3yA03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.220	Chondroitinase Ac; Chain A, domain 3
	2.60.220.10	Polysaccharide lyase family 8-like, C-terminal

Domain Context

CATH Clusters

Superfamily	Polysaccharide lyase family 8-like, C-terminal
Functional Family

Enzyme Information

4.2.2.1

Hyaluronate lyase.

based on mapping to UniProt Q54873

Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4- enuronosyl)-N-acetyl-D-glucosamine.

-!- The enzyme catalyzes the degradation of hyaluronan by a beta- elimination reaction. -!- Also acts on chondroitin. -!- The product is more systematically known as 3-(4-deoxy-alpha-L-threo- hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose. -!- Formerly EC 4.2.99.1.

UniProtKB Entries (1)

Q54873

HYSA_STRPN

Streptococcus pneumoniae TIGR4

Hyaluronate lyase

PDB Structure

PDB	1W3Y
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	L-Ascorbic Acid 6-Hexadecanoate, a Potent Hyaluronidase Inhibitor: X-Ray Structure and Molecular Modeling of Enzyme-Inhibitor Complexes Botzki, A., Rigden, D.J., Braun, S., Nukui, M., Salmen, S., Hoechstetter, J., Bernhardt, G., Dove, S., Jedrzejas, M.J., Buschauer, A. J.Biol.Chem.