CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.30 | Glutaredoxin | |
3.40.30.10 | Glutaredoxin |
Domain Context
CATH Clusters
Superfamily | Glutaredoxin |
Functional Family |
Enzyme Information
2.5.1.18 |
Glutathione transferase.
based on mapping to UniProt P08263
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
|
1.11.1.- |
Peroxidases.
based on mapping to UniProt P08263
|
5.3.3.- |
Transposing C=C bonds.
based on mapping to UniProt P08263
|
UniProtKB Entries (1)
P08263 |
GSTA1_HUMAN
Homo sapiens
Glutathione S-transferase A1
|
PDB Structure
PDB | 1USB |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Incorporation of a Single His Residue by Rational Design Enables Thiol-Ester Hydrolysis by Human Glutathione Transferase A1-1
Proc.Natl.Acad.Sci.USA
|