CATH Domain 1ua4A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1190	UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
	3.40.1190.20	Ribokinase

Domain Context

CATH Clusters

Superfamily	3.40.1190.20
Functional Family

Enzyme Information

2.7.1.147

ADP-specific glucokinase.

based on mapping to UniProt Q9V2Z6

ADP + D-glucose = AMP + D-glucose 6-phosphate.

-!- The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. -!- No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.

UniProtKB Entries (1)

Q9V2Z6

GLKA_PYRFU

Pyrococcus furiosus DSM 3638

ADP-dependent glucokinase

PDB Structure

PDB	1UA4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of an ADP-dependent glucokinase from Pyrococcus furiosus: implications for a sugar-induced conformational change in ADP-dependent kinase Ito, S., Fushinobu, S., Jeong, J.J., Yoshioka, I., Koga, S., Shoun, H., Wakagi, T. J.Mol.Biol.