CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | 3-hydroxyacyl-CoA dehydrogenase type-2 |
Enzyme Information
| 1.1.1.178 |
3-hydroxy-2-methylbutyryl-CoA dehydrogenase.
based on mapping to UniProt Q99714
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH.
-!- Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
|
| 1.1.1.51 |
3(or 17)-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt Q99714
Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H.
-!- Also acts on other 3-beta- or 17-beta-hydroxysteroids (cf. EC 1.1.1.209).
|
| 1.1.1.35 |
3-hydroxyacyl-CoA dehydrogenase.
based on mapping to UniProt Q99714
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
|
UniProtKB Entries (1)
| Q99714 |
HCD2_HUMAN
Homo sapiens
3-hydroxyacyl-CoA dehydrogenase type-2
|
PDB Structure
| PDB | 1SO8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
Science
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