CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.70 | Cathepsin D, subunit A; domain 1 |
|
2.40.70.10 | Acid Proteases |
Domain Context
CATH Clusters
| Superfamily | Acid Proteases |
| Functional Family | renin |
Enzyme Information
| 3.4.23.15 |
Renin.
based on mapping to UniProt P00796
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.
|
UniProtKB Entries (2)
| P01015 |
ANGT_RAT
Rattus norvegicus
Angiotensinogen
|
| P00796 |
RENI2_MOUSE
Mus musculus
Renin-2
|
PDB Structure
| PDB | 1SMR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.
J.Mol.Biol.
|
