CATH Domain 1przA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.2350	Pseudouridine synthase
	3.30.2350.10	Pseudouridine synthase

Domain Context

CATH Clusters

Superfamily	Pseudouridine synthase
Functional Family

Enzyme Information

5.4.99.23

23S rRNA pseudouridine(1911/1915/1917) synthase.

based on mapping to UniProt P33643

23S rRNA uridine(1911)/uridine(1915)/uridine(1917) = 23S rRNA pseudouridine(1911)/pseudouridine(1915)/pseudouridine(1917).

-!- Pseudouridine synthase RluD converts uridines at positions 1911, 1915, and 1917 of 23S rRNA to pseudouridines. -!- These nucleotides are located in the functionally important helix- loop 69 of 23S rRNA.

UniProtKB Entries (1)

P33643

RLUD_ECOLI

Escherichia coli K-12

Ribosomal large subunit pseudouridine synthase D

PDB Structure

PDB	1PRZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the RluD pseudouridine Synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli Sivaraman, J., Iannuzzi, P., Cygler, M., Matte, A. J.Mol.Biol.